lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer
Braz. j. med. biol. res
;
53(1): e8883, Jan. 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1055486
ABSTRACT
Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is one kind of cytoplasmic long non-coding RNA (lncRNA), which has been demonstrated to play a critical function in multiple cancers. However, the detailed mechanism of OIP5-AS1 in the regulation of cervical cancer progression is still obscure. Here, we demonstrated that lncRNA OIP5-AS1 was upregulated in cervical cancer and was correlated with poor prognosis by bioinformatics studies. OIP5-AS1 depletion inhibited cell proliferation and promoted cell apoptosis in cervical cancer cells. Furthermore, we clarified that ROCK1 was the downstream effector of OIP5-AS1 and OIP5-AS1 acted as a molecular sponge of miR-143-3p. Finally, we verified that OIP5-AS1 exerted its function in the regulation of cervical cancer progression via interacting with miR-143-3p to regulate ROCK1 expression. Our study revealed novel mechanisms about how lncRNA OIP5-AS1 executed its function in cervical cancer and thus provided potential therapeutic targets for the disease.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Neoplasias del Cuello Uterino
/
Apoptosis
/
MicroARNs
/
Proliferación Celular
/
Quinasas Asociadas a rho
/
ARN Largo no Codificante
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
General Hospital of Ningxia Medical University/CN
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