Soluble Human Leukocyte Antigen Molecules Detected in Orofacial Cleft Patients: A Case-Control Study
Pesqui. bras. odontopediatria clín. integr
;
20: e5096, 2020. tab
Artículo
en Inglés
| LILACS, BBO
| ID: biblio-1056880
ABSTRACT
Abstract Objective:
To compare soluble HLA-C and HLA-DR molecules present in the plasma of orofacial cleft and non-orofacial cleft populations. Material andMethods:
Orofacial cleft patients were recruited using an accidental sampling approach (n=15). Peripheral blood was collected from the participants and processed for Enzyme Linked Immunosorbent Assay (ELISA) against HLA-C and HLA-DR with specific antibodies. The absorbance was calculated utilizing ELISA reader. Data were statistically analyzed using an independent t-test to compare the disease and control groups.Results:
The levels of soluble HLA-C and HLA-DR were significantly higher in the diseased group compared to the control group (p<0.05).Conclusion:
The role of HLA molecules in non-communicable disease and congenital anomalies, particularly orofacial cleft, remains speculative despite the positive results of this study and those of previous investigations. It suggests that the variables examined may affect specific pathways involved in the pathogenesis of orofacial cleft, and predispose the individuals concerned to the oral cleft.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Antígenos HLA-C
/
Antígenos HLA-DR
/
Estudios de Casos y Controles
/
Patogenesia Homeopática
/
Labio Leporino
Tipo de estudio:
Estudio observacional
Límite:
Adolescente
/
Niño
/
Femenino
/
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Pesqui. bras. odontopediatria clín. integr
Asunto de la revista:
Odontología
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Indonesia
Institución/País de afiliación:
Universitas Airlangga/ID
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