In vivo antileishmanial activity of Annona mucosa extracts
Rev. Soc. Bras. Med. Trop
;
53: e20190139, 2020. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1057288
ABSTRACT
Abstract INTRODUCTION: Leishmaniasis, a disease caused by a parasite endemic to large areas of tropical and subtropical countries, is a growing public health problem. METHODS: Male BALB/c mice were infected with Leishmania amazonensis and treated with extracts isolated from Annona mucosa. RESULTS: Treated groups had significantly reduced footpad swelling. The group treated intraperitoneally with hexane extract showed footpad swelling similar to groups treated with Pentamidine® and Glucantime®. Groups treated with dichloromethane extract and hexane extract presented the recovering phenotype associated with reduced parasite levels. CONCLUSIONS: Extracts of A. mucosa are promising sources of novel antileishmanial compounds.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Extractos Vegetales
/
Leishmaniasis Cutánea
/
Annona
/
Leishmania
/
Antiprotozoarios
Límite:
Animales
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual de Santa Cruz/BR
/
Universidade Federal do Amazonas/BR
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