Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C
Rev. Soc. Bras. Med. Trop
;
53: e20190210, 2020. tab
Artículo
en Inglés
| LILACS
| ID: biblio-1057300
ABSTRACT
Abstract INTRODUCTION:
Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C.METHODS:
Patients (159) with chronic hepatitis C of both genders were analyzed.RESULTS:
Women showed association between HPA-3 polymorphisms and RM.CONCLUSIONS:
An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Polimorfismo Genético
/
Enfermedades Reumáticas
/
Antígenos de Plaqueta Humana
/
Hepatitis C Crónica
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual Paulista/BR
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