Platelet/lymphocyte ratio and mean platelet volume in patients with granulomatosis with polyangiitis
Adv Rheumatol
;
60: 04, 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1088643
ABSTRACT
Abstract Background:
Granulomatosis with polyangiitis (GPA) is a granulomatous necrotizing vasculitis with high morbidity and mortality. Anti-neutrophil cytoplasmic antibody is a valuable diagnostic marker, however its titer lacks predictive value for the severity of organ involvement. Platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) has been regarded as a potential marker in assessing systemic inflammation. We aimed to explore the value of PLR and MPV in the assessment of disease activity and manifestations of disease in GPA.Methods:
56 newly diagnosed GPA patients and 53 age-sex matched healthy controls were included in this retrospective and cross-sectional study with comparative group. Complete blood count was performed with Backman Coulter automatic analyzer, erythrocyte sedimentation rate (ESR) with Westergen method and C-reactive protein (CRP) levels with nephelometry. The PLR was calculated as the ratio of platelet and lymphocyte counts.Result:
Compared to control group, ESR, CRP and PLR were significantly higher and MPV significantly lower in GPA patients. In patients group, PLR was positively correlated with ESR and CRP (r = 0.39, p = 0.005 and r = 0.51, p < 0.001, respectively). MPV was negatively correlated with ESR and CRP (r = - 0.31, p = 0.028 and r = - 0.34 p = 0.014, respectively). Patients with renal involvement had significantly higher PLR than patients without renal involvement (median265.98, IQR208.79 vs median180.34 IQR129.37, p = 0.02). PLR was negatively correlated with glomerular filtration rate (r = - 0.27, p = 0.009). A cut-off level of 204 for PLR had 65.6% sensitivity and 62.5 specificity to predict renal involvement.Conclusion:
PLR exhibit favorable diagnostic performance in predicting renal involvement in patients with GPA.(AU)
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Linfocitos
/
Granulomatosis con Poliangitis
/
Volúmen Plaquetario Medio
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Adv Rheumatol
Asunto de la revista:
Artrite
/
Reumatologia
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Gazi University/TR
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