Radioprotective profile of Urtica dioica L. seed extract on oxidative DNA-damage in liver tissue and whole blood of radiation-administered rats
Braz. J. Pharm. Sci. (Online)
;
56: e18382, 2020. tab, graf
Artículo
en Inglés
|
LILACS-Express
| LILACS
| ID: biblio-1089203
ABSTRACT
It was aimed to investigate the radioprotective activity of Urtica dioica L. seed extract (UDSE) in the whole blood and liver of radiation-administered rats, both biochemically and immunohistochemically. 32 rats were divided into 4 groups (n8). Control group (C) no administration for 10 days. Radiation group (IR) fed pellets for 10 days after exposure to radiation. Radiation + UDSE (IR+UDSE) group exposed to radiation and fed UDSE for 10 days. UDSE group (UDSE) fed UDSE for 10 days. Radiation (5Gy) was given as a single fraction. 8-hydroxy-2-deoxyguanosine (8-OHdG) and deoxyguanosine (dG) levels were analyzed by biochemical method and glutathione peroxidase 1 (GPx-1) analyses were performed by immunohistochemical method in the liver and blood tissues of the rats. The increased 8-OHdG rates and decreased GPx-1 immunoreactivity was observed in the IR group. Those parameters were ameliorated in the IR+UDSE group when compared to the IR group. UDSE is likely to be a valuable radioprotector against the harmful effects of radiation.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Idioma:
Inglés
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2020
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Turquía
Institución/País de afiliación:
Van Yuzuncu Yil Universit/TR
/
Van Yuzuncu Yil University/TR
Similares
MEDLINE
...
LILACS
LIS