Biological bases for a possible effect of cannabidiol in Parkinson's disease
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
42(2): 218-224, Mar.-Apr. 2020.
Artículo
en Inglés
| LILACS
| ID: biblio-1089257
ABSTRACT
Current pharmacotherapy of Parkinson's disease (PD) is palliative and unable to modify the progression of neurodegeneration. Treatments that can improve patients' quality of life with fewer side effects are needed, but not yet available. Cannabidiol (CBD), the major non-psychotomimetic constituent of cannabis, has received considerable research attention in the last decade. In this context, we aimed to critically review the literature on potential therapeutic effects of CBD in PD and discuss clinical and preclinical evidence supporting the putative neuroprotective mechanisms of CBD. We searched MEDLINE (via PubMed) for indexed articles published in English from inception to 2019. The following keywords were used cannabis; cannabidiol and neuroprotection; endocannabinoids and basal ganglia; Parkinson's animal models; Parkinson's history; Parkinson's and cannabidiol. Few studies addressed the biological bases for the purported effects of CBD on PD. Six preclinical studies showed neuroprotective effects, while three targeted the antidyskinetic effects of CBD. Three human studies have tested CBD in patients with PD an open-label study, a case series, and a randomized controlled trial. These studies reported therapeutic effects of CBD on non-motor symptoms. Additional research is needed to elucidate the potential effectiveness of CBD in PD and the underlying mechanisms involved.
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Índice:
LILACS (Américas)
Asunto principal:
Enfermedad de Parkinson
/
Cannabidiol
/
Fármacos Neuroprotectores
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Asunto de la revista:
Psiquiatria
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Departamento de Neurociências e Ciências do Comportamento, FMRP, USP/BR
/
Faculdade de Odontologia de Ribeirão Preto (FORP), USP/BR
/
Prati Donaduzzi & Cia Ltda./BR
/
Universidade de São Paulo (USP)/BR
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