Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
Braz. j. infect. dis
;
24(1): 85-88, Feb. 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1089325
ABSTRACT
ABSTRACT The antigenic potential of seven immunogenic peptides of the dengue virus was evaluated in the sera of patients with dengue confirmed by IgM/IgG serology. Antibodies IgM and IgG against dengue virus peptides were analyzed by ELISA in 31 dengue sero-positive and 20 sero-negative patients. The P5 peptide showed significant IgG immunoreactivity mostly in the sera of patients with dengue without warning signs in comparison with patients with dengue with warning signs, correlating with mild disease. This finding suggests that the low antibody response against P5 epitope could be a risk factor for higher susceptibility to dengue virus infection with warning signs, and that P5 could be a potential antigen for vaccine development.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Péptidos
/
Proteínas del Envoltorio Viral
/
Virus del Dengue
/
Vacunas contra el Dengue
/
Anticuerpos Antivirales
/
Epítopos
Tipo de estudio:
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
México
Institución/País de afiliación:
Hospital Regional 1 "Lic. Ignacio García Téllez"/MX
/
Universidad Autónoma de Yucatán/MX
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