Pretreatment plasma fibrinogen level as a prognostic biomarker for patients with lung cancer
Clinics
;
75: e993, 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1089599
ABSTRACT
Many researchers have shown that pretreatment plasma fibrinogen levels are closely correlated with the prognosis of patients with lung cancer (LC). In this study, we thus performed a meta-analysis to systematically assess the prognostic value of pretreatment plasma fibrinogen levels in LC patients. A computerized systematic search in PubMed, EMBASE, Web of Science and China National Knowledge Infrastructure (CNKI) was performed up to March 15, 2018. Studies with available data on the prognostic value of plasma fibrinogen in LC patients were eligible for inclusion. The pooled hazard ratios (HRs) and odd ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the correlation between pretreatment plasma fibrinogen levels and prognosis as well as clinicopathological characteristics. A total of 17 studies with 6,460 LC patients were included in this meta-analysis. A higher pretreatment plasma fibrinogen level was significantly associated with worse overall survival (OS) (HR 1.57; 95% CI 1.39-1.77; p=0.001), disease-free survival (DFS) (HR 1.53; 95% CI 1.33-1.76; p=0.003), and progression-free survival (PFS) (HR 3.14; 95% CI 2.15-4.59; p<0.001). Furthermore, our subgroup and sensitivity analyses demonstrated that the pooled HR for OS was robust and reliable. In addition, we also found that a higher fibrinogen level predicted advanced TNM stage (III-IV) (OR=2.18, 95% CI 1.79-2.66; p<0.001) and a higher incidence of lymph node metastasis (OR=1.74, 95% CI 1.44-2.10; p=0.02). Our study suggested that higher pretreatment plasma fibrinogen levels predict worse prognoses in LC patients.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Fibrinógeno
/
Carcinoma de Pulmón de Células no Pequeñas
/
Neoplasias Pulmonares
Tipo de estudio:
Estudio pronóstico
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
The Third Affiliated Hospital of Sun Yat-sen University/CN
/
The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Tianhe District/CN
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