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Evaluation of the physical and antifungal effects of chlorhexidine diacetate incorporated into polymethyl methacrylate
Maluf, Caroline Vieira; Peroni, Luciana Vieira; Menezes, Lívia Rodrigues; Coutinho, Wagner; Lourenço, Eduardo José Veras; Telles, Daniel de Moraes.
Afiliación
  • Maluf, Caroline Vieira; Universidade do Estado do Rio de Janeiro. Departamento de Prótese Dentária. Rio de Janeiro. BR
  • Peroni, Luciana Vieira; Universidade do Estado do Rio de Janeiro. Departamento de Prótese Dentária. Rio de Janeiro. BR
  • Menezes, Lívia Rodrigues; Universidade Federal do Rio de Janeiro. Instituto de Macromoléculas Eloisa Mano. Rio de Janeiro. BR
  • Coutinho, Wagner; Universidade do Estado do Rio de Janeiro. Rio de Janeiro. BR
  • Lourenço, Eduardo José Veras; Universidade do Estado do Rio de Janeiro. Departamento de Prótese Dentária. Rio de Janeiro. BR
  • Telles, Daniel de Moraes; Universidade do Estado do Rio de Janeiro. Departamento de Prótese Dentária. Rio de Janeiro. BR
J. appl. oral sci ; J. appl. oral sci;28: e20190039, 2020. tab, graf
Article en En | LILACS, BBO | ID: biblio-1090769
Biblioteca responsable: BR28.1
ABSTRACT
Abstract This study aimed to evaluate the physical properties and antifungal activities of polymethyl methacrylate (PMMA) acrylic resins after the incorporation of chlorhexidine diacetate salt (CDA).

Methodology:

First, acrylic resin specimens were fabricated with Vipi Cor® and DuraLay® resins with and without the incorporation of 0.5%, 1.0% or 2.0% CDA. The residual monomer and CDA release were measured at intervals ranging from 2 hours to 28 days using ultraviolet spectrometry combined with high-performance liquid chromatography. The antifungal activity against C. albicans was evaluated with the agar diffusion method. Fourier transform infrared spectroscopy was used to analyze the degree of resin conversion. Finally, the water sorption values of the resins were also measured.

Results:

The incorporated CDA concentration significantly changed the rate of CDA release (p<0.0001); however, the brand of the material appeared to have no significant influence on drug release. Subsequently, the inhibition zones were compared between the tested groups and within the same brand, and only the comparisons between the CDA 2% and CDA 1% groups and between the CDA 1% and CDA 0.5% groups failed to yield significant differences. Regarding the degrees of conversion, the differences were not significant and were lower only in the CDA 2% groups. Water sorption was significantly increased at the 1.0% and 2.0% concentrations.

Conclusions:

We concluded that the incorporation of CDA into PMMA-based resins enabled the inhibition of C. albicans growth rate, did not alter the degrees of conversion of the tested resins and did not change the release of residual monomers.
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Texto completo: 1 Índice: LILACS Asunto principal: Clorhexidina / Polimetil Metacrilato / Antifúngicos Tipo de estudio: Evaluation_studies Idioma: En Revista: J. appl. oral sci Asunto de la revista: ODONTOLOGIA Año: 2020 Tipo del documento: Article

Texto completo: 1 Índice: LILACS Asunto principal: Clorhexidina / Polimetil Metacrilato / Antifúngicos Tipo de estudio: Evaluation_studies Idioma: En Revista: J. appl. oral sci Asunto de la revista: ODONTOLOGIA Año: 2020 Tipo del documento: Article