Vll Edition of Quincke´s Scholarship: Lecture Highlights

ABSTRACT

Introduction: Quincke´s Scholarship deals with themes related to neuroinmunology and the complement system. Objective: Describe the most recent advances of the Vll Edition of Quincke´s Scholarship. Methods: Publications pertaining to Quincke´s Scholarship were selected and revised from the work group of the Central Lab of Cerebrospinal fluid (LABCEL). Results: The principal topic was the C1q protein; initiator of the clasic complement pathway. From the analisis of the molecular concentration of this protein, its transference and the correlations between the concentration of C1q protein in cerebrospinal fluid (LCR) and the quotient of albumin (QAlb) between LCR and plasma it is hypothesized that an intratecal synthesis of the C1q in patients with a disfunction of the blood-brain barrier. The most recently discovered pathway in the activation of the complement is the lectin pathway. The diffusion of the MASP-3 protein from blood to LCR is proof that the MASP-3 is synthesized in the leptomeninges. The reibergram is useful to evaluate the inmune response in patients with neurological manifestations caused by the dengue virus, and patients with multiple sclerosis. Conclusions: The Vll Edition of Quincke´s Scholarship dealt with C1q protein and recently discovered themes of the lectin pathway and the use of the reibergram(AU)