Erradicación de Helicobacter pylori, consideraciones clínicas según la edad / Helicobacter pylori eradication, clinical considerations related to age
Gastroenterol. latinoam
;
30(supl.1): S18-S25, 2019. ilus, tab, graf
Artículo
en Español
| LILACS
| ID: biblio-1116305
RESUMEN
Helicobacter pylori (H. pylori) is a gram negative bacteria that survives in the gastric acid environment. The infection is acquired mainly during childhood. Fifty to 70% of adult population has the infection. However, in the last 10 year, a decrease in the prevalence of this infection has been observed in all age groups, in particular in pediatric population and elderly patients over 60 years old. The evolution of the infection depends on bacterial factors (virulence and toxins) and host immune response. People infected mainly develop gastrointestinal diseases such as gastritis, peptic ulcer and MALT lymphoma. H. pylori infection is the main risk factor of gastric cancer and for that reason, the eradication is recommended if H. pylori has been detected through invasive or non-invasive tests. Among children, eradication is not recommended unless there is a clinical manifestation that merits. H. pylori eradication is recommended in symptomatic adults and there is a controversy about massive eradication in asymptomatic population due to the risk of development of antibiotic resistance. Treatment is based on the use of proton pump inhibitors (PPI) associated to antibiotics, that should be chosen taking into account the increasing antibiotic resistance, and local availability. Clarithromycin (CLA) and levofloxacin resistance is increasingly high, and CLA-free quadruple therapy schemes are currently recommended for first-line therapy. H. pylori eradication must be confirmed with invasive or non-invasive tests. Second-line therapy based on antibiotics not previously used, PPI high doses and bismuth is recommended.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Infecciones por Helicobacter
Tipo de estudio:
Estudio diagnóstico
/
Factores de riesgo
Límite:
Adulto
/
Niño
/
Humanos
Idioma:
Español
Revista:
Gastroenterol. latinoam
Asunto de la revista:
Gastroenterologia
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Pontificia Universidad Católica de Chile/CL
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