Síndrome de Schnitzler tratado con canakinumab / Schnitzler syndrome treated with canakinumab

RESUMEN

El síndrome de Schnitzler es un raro trastorno caracterizado por rash urticariano crónico y gammapatía monoclonal, acompañado de fiebre intermitente, artralgias o artritis, dolor óseo y linfadenopatías, en el cual la interleuquina 1 (IL-1) tiene un papel preponderante. Se presenta el caso de un varón de 48 años que reúne criterios para síndrome de Schnitzler y que luego de fallar a múltiples tratamientos presenta respuesta exitosa a canakinumab

ABSTRACT

Schnitzler syndrome is a rare disorder characterized by chronic urticarial rash and monoclonal gammopathy, accompanied by intermittent fever, arthralgia or arthritis, bone pain and lymphadenopathy, in which interleukin 1 (IL-1) has a preponderant role. The case of a 48-year-old male who meets criteria for Schnitzler syndrome and who after failing too many treatments presents a successful response to canakinumab is presented here