Evaluation of the extent of interstitial fibrosis in oral squamous cell carcinoma compared with normal oral mucosa and oral epithelial dysplasia
J. oral res. (Impresa)
;
7(2): 51-54, feb. 18, 2018. ilus, tab
Artículo
en Inglés
| LILACS
| ID: biblio-1120390
ABSTRACT
Objective:
to evaluate the extent of interstitial fibrosis in samples of normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Materials andmethod:
descriptive study. eighteen samples of NOM, 15 samples of OED, and 13 samples of OSCC were analyzed; all stained with Masson's trichrome stain. the areas of greatest fibrosis underlying the normal, dysplastic, and malignant neoplastic oral epithelium were identified in order to determine the extent of interstitial fibrosis. interstitial fibrosis was classified according to its proportion in the total image, being 0 (without fibrosis), +1 (1-25 percent), 2+ (26-50 percent), 3+ (51-75 percent) and +4 (76-100 percent). variables were analyzed using the Kruskal-Wallis test and Dunn's Pairwise post-hoc test.Results:
the samples of NOM and OED did not present interstitial fibrosis (type 0) in the majority of the cases respectively. OSCC samples were characterized by an extension of type 2+ interstitial fibrosis in 45 percent of all cases of OSCC. the extent of interstitial fibrosis was different between NOM and OSCC (p<0.001), and between OED and OSCC (p<0.001).Conclusion:
the extent of interstitial fibrosis is directly proportional to the malignization of the analyzed samples, being an adequate marker for OSCC.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Fibrosis de la Submucosa Bucal
/
Carcinoma de Células Escamosas
/
Mucosa Bucal
Tipo de estudio:
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Anciano
/
Aged80
/
Niño
/
Humanos
Idioma:
Inglés
Revista:
J. oral res. (Impresa)
Asunto de la revista:
Odontología
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Universidad Andrés Bello/CL
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