Primum non nocere - Are chloroquine and hydroxychloroquine safe prophylactic/treatment options for SARS-CoV-2 (covid-19)?
Rev. saúde pública (Online)
;
54: 68, 2020. graf
Artículo
en Inglés
| BBO, LILACS
| ID: biblio-1127241
ABSTRACT
ABSTRACT Chloroquine (CQ) and its analog hydroxychloroquine (HCQ) were recently included in several clinical trials as potential prophylactic and therapeutic options for SARS-COV-2 infection/covid-19. However, drug effectiveness in preventing, treating, or slowing the progression of the disease is still unknown. Despite some initial promising in vitro results, rigorous pre-clinical animal studies and randomized clinical trials have not been performed yet. On the other hand, while the potential effectiveness of CQ/HCQ is, at best, hypothetical, their side effects are factual and most worrisome, particularly when considering vulnerable groups of patients being treated with these drugs. in this comment, we briefly explain the possible mechanisms of action of CQ/HCQ for treating other diseases, possible actions against covid-19, and their potent side effects, in order to reinforce the necessity of evaluating the benefit-risk balance when widely prescribing these drugs for SARS-COV-2 infection/covid-19. We conclude by strongly recommending against their indiscriminate use.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neumonía Viral
/
Cloroquina
/
Infecciones por Coronavirus
/
Betacoronavirus
/
Hidroxicloroquina
/
Antimaláricos
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de etiología
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. saúde pública (Online)
Asunto de la revista:
Sa£de P£blica
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Estados Unidos
Institución/País de afiliación:
University of Texas-Arlington/US
Similares
MEDLINE
...
LILACS
LIS