Modelo de indução de osteoporose em coelhas - avaliação radiográfica / Rabbit osteoporosis induction model - radiographic evaluation
Arq. bras. med. vet. zootec. (Online)
;
72(2): 633-636, Mar./Apr. 2020. ilus, graf
Artículo
en Portugués
| LILACS, VETINDEX
| ID: biblio-1128494
ABSTRACT
In order to establish a bone loss induction model in rabbits to study osteoporosis, 18 rabbits underwent ovariectomy and received methylprednisolone 1mg/kg intramuscularly on alternate days for two weeks. Immediately before ovariectomy up to 42 days after methylprednisolone administration, radiographs of the right olecranon were taken in the mediolateral position to evaluate the radiographic optical density. Before the induction of osteoporosis, rabbits presented mean values of radiographic density of 2.305mm Al and at 42 days of 1.575mm Al. The values obtained were submitted to ANOVA for repeated measures that revealed a significant drop (P< 0.001) in the density over time, proving that the induction was able to trigger bone loss of these animals. With this, it can be affirmed that the adopted protocol was enough to provoke a significant bone loss, characterizing a valid model for the study of new treatments for osteoporosis.(AU)
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Osteoporosis
/
Regeneración Ósea
/
Densidad Ósea
Tipo de estudio:
Guía de Práctica Clínica
Límite:
Animales
Idioma:
Portugués
Revista:
Arq. bras. med. vet. zootec. (Online)
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Universidade Federal de Viçosa/BR
/
Universidade Vila Velha/BR
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