Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats
Acta cir. bras
;
35(3): e202000302, 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1130624
ABSTRACT
Abstract Purpose:
To evaluate the healing potential of the electrospinning membranes of Poly (Lactic Acid) (PLA) associated with Sedum dendroideum extract in burn injuries in rats.Methods:
Seventy-five rats were submitted to burn injury on their back skin (C) untreated; (F) with daily topical application of S. dendroideum extract; (M) with electrospinning membranes of PLA; (MF10) with electrospinning membranes of PLA with 10% S. dendroideum extract; (MF25) with electrospinning membranes of PLA with 25% S. dendroideum extract. Tissue samples were taken after 2, 6 and 14 days of the burn injury and were subjected to histomorfometric analysis of quantification of fibroblasts, collagen fibers, blood vessels, and inflammatory infiltrateResults:
The histomorphometric analysis showed an increase in the number of fibroblasts, collagen fibers and blood vessels in the burns treated with membranes of PLA, associated or not with the 10% and 25% extract. The extract of S. dendroideum promoted the increase of collagen fibers.Conclusion:
The electrospinning PLA membrane, isolated or associated with the S. dendrodeum extract, favored the healing of burn injuries in this experimental model, with an increase of fibroblasts, collagen fibers, and blood vessels. S. dendroideum isolated only stimulated the collagenesis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Poliésteres
/
Cicatrización de Heridas
/
Quemaduras
/
Extractos Vegetales
/
Sedum
/
Membranas Artificiales
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
FHO/BR
/
Fundação Hermínio Ometto/BR
/
Universidade Estadual de Campinas/BR
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