Small fiber neuropathy and related factors in patients with systemic lupus erythematosus; the results of cutaneous silent period and skin biopsy
Adv Rheumatol
;
60: 31, 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1130800
ABSTRACT
Abstract Introduction Evaluating small nerve fibers in patients with systemic lupus erythematosus (SLE) using cutaneous silent period (CSP) and skin biopsy and assesssing the relationship between clinical signs, autoantibodies and neuropathic pain score. Objective - methods Fifty one SLE patients and 46 healthy volunteers were included in this study. Nerve conduction studies and CSP were performed both on upper and lower limbs in subjects. Skin biopsy was performed and the number of epidermal nerve density and IL-6 staining were evaluated. Results In SLE patients, CSP latencies were significantly prolonged both in lower and upper limbs and lower and upper extremity CSP durations were significantly shorter when compared to controls ( p < 0.001). The number of epidermal nerve was significantly lower in SLE patients when compared to healthy controls ( p < 0.001). Conclusion We detected marked small nerve fiber damage in both lower and upper limbs in SLE patients using CSP. Decreased epidermal nerve density also supports this finding.(AU)
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neuropatía de Fibras Pequeñas
/
Lupus Eritematoso Sistémico
Límite:
Humanos
Idioma:
Inglés
Revista:
Adv Rheumatol
Asunto de la revista:
Artrite
/
Reumatologia
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Medikent Hospital/TR
/
Memorial Hizmet hospital/TR
/
Trakya University Medical Faculty/TR
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