Worse survival of invasive melanoma patients in men and de novo lesions
An. bras. dermatol
;
95(2): 158-164, Mar.-Apr. 2020. tab
Artículo
en Inglés
| LILACS, ColecionaSUS
| ID: biblio-1130841
ABSTRACT
Abstract Background:
The incidence and mortality of melanoma is increasing in many countries, including Brazil. Survival studies are still scarce in our country, but much needed to know and address this problem better.Objective:
To analyze the disease-specific survival of patients with invasive melanoma and to correlate it with clinical and histopathological variables.Methods:
Retrospective cohort analysis of 565 cases of invasive melanoma in a tertiary hospital with the objective of testing variables that could be associated with a worse prognosis, such as gender, phototype, thickness, histological type and presence of pre-existing clinical lesion at the site of the tumor.Results:
The worst survival rates were significantly associated with thicker tumors (p < 0.001), male sex (p = 0.014), high phototype (p = 0.047), nodular melanoma (p = 0.024) and "de novo" lesions (p = 0.005). When all variables were adjusted for melanoma thickness, male patients (p = 0.011) and "de novo" melanomas (p = 0.025) remained associated with worse survival. Studylimitations:
Retrospective study of a single tertiary hospital.Conclusions:
Although the causes are still unknown, melanoma-specific survival was statistically worse for males and for "de novo" melanomas even after adjustment of tumor thickness.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neoplasias Cutáneas
/
Melanoma
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Aged80
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Lactante
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
An. bras. dermatol
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Fundação Sistema Estadual de Análise de Dados/BR
/
Universidade de São Paulo/BR
Similares
MEDLINE
...
LILACS
LIS