Analysis of filaggrin 2 gene polymorphisms in patients with atopic dermatitis
An. bras. dermatol
;
95(2): 173-179, Mar.-Apr. 2020. tab
Artículo
en Inglés
| LILACS, ColecionaSUS
| ID: biblio-1130863
ABSTRACT
Abstract Background:
Polymorphisms of the filaggrin 2 gene (rs 12568784 and rs 16899374) are associated with persistent atopic dermatitis in African American patients. Filaggrin 2 is a protein with a function similar to filaggrin and also encoded in the epidermal differentiation complex on chromosome 1q21.Objective:
To evaluate the polymorphisms in the filaggrin 2 gene (rs 12568784 and rs 16899374) in children and adults with atopic dermatitis and to verify the association of these with the severity of the clinical picture, presence of other allergic diseases, and socio-demographic factors.Method:
The study was carried out with patients and control group. Questionnaires were used to evaluate ethnicity, sex, age, family history, scoring, atopic dermatitis (SCORAD), among other parameters. Genotyping of the filaggrin 2 gene was performed by real-time polymerase chain reaction.Results:
Forty-eight patients and 83 controls were evaluated. No correlation was found between the variables studied in patients with atopic dermatitis and polymorphisms, no significant difference between the prevalence of polymorphisms in the patients and in the control group p > 0.05. Study limits The exclusive use of self-reported ethnicity information and the sample size.Results:
The results of this work can be an incentive for the study of the polymorphisms in atopic dermaititis, considering the characteristic of the Brazilian multi ethnic population.Conclusion:
This is an unpublished work in Brazil and the first study in the world to have a control group to evaluate alterations in the gene of filaggrin 2.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Polimorfismo Genético
/
Proteínas S100
/
Dermatitis Atópica
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Lactante
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
An. bras. dermatol
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Instituto de Dermatologia Prof. Rubem David Azulay/BR
/
State University of Rio de Janeiro/BR
/
Universidade do Estado do Rio de Janeiro/BR
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