ß-Catenin: oncogenic role and therapeutic target in cervical cancer
Biol. Res
;
53: 33, 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1131890
ABSTRACT
Cervical cancer is a common and fatal malignancy of the female reproductive system. Human papillomavirus (HPV) is the primary causal agent for cervical cancer, but HPV infection alone is insufficient to cause the disease. Actually, most HPV infections are sub-clinical and cleared spontaneously by the host immune system; very few persist and eventually develop into cervical cancer. Therefore, other host or environmental alterations could also contribute to the malignant phenotype. One of the candidate co-factors is the ß-catenin protein, a pivotal component of the Wnt/ß-catenin signaling pathway. ß-Catenin mainly implicates two major cellular activities cell-cell adhesion and signal transduction. Recent studies have indicated that an imbalance in the structural and signaling properties of ß-catenin leads to various cancers, such as cervical cancer. In this review, we will systematically summarize the role of ß-catenin in cervical cancer and provide new insights into therapeutic strategies.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neoplasias del Cuello Uterino
/
Infecciones por Papillomavirus
/
Beta Catenina
/
Vía de Señalización Wnt
/
Carcinogénesis
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Central South University/CN
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