Role of ACE2 Gene Expression in Renin Angiotensin System and Its Importance in Covid-19: In Silico Approach
Braz. arch. biol. technol
;
63: e20200304, 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1132259
ABSTRACT
Abstract We aimed to analyze the expression profile of ACE2 and similar genes with ACE2, predict the number of variations in ACE2, detect the suspected SNPs on ACE2 gene, and perform the pathway analysis of renin-angiotensin system (RAS) and protein absorption-digestion. Moreover, we have predicted the gene-related diseases with ACE2. STRING was used to analyze functionally similar genes with ACE2. Exome Variant Server, SIFT, Polyphen2 were used to predict the number of variations in ACE2 and detect the suspected SNPs on ACE2. KEGG database and STRING were used to draw pathway of ACE2. Then, DISEASES resource, FitSNPs, UniProt, BioXpress, IGV Browser, Ensembl Genome Browser, and UCSC Genome Browser were used to predict the ACE2 gene-related diseases and expression profile in human normal and cancer tissues. We have shown that expression of ACE2 was correlated with AGT, REN, AGTR1, AGRT2, MME2, DPP4, PRCP, MEP1A, XPNPEP2, MEP1BandACE2 is expressed in testis, kidney, heart, thyroid, colon, esophagus, breast, minor salivary gland, pancreas, lung, liver, bladder, cervix, and muscle tissues. We found 99 variations in ACE2 gene, in which no previous study has been performed. In the future, this in silico analysis should be combined with other pieces of evidence including experimental data to assign function.
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Índice:
LILACS (Américas)
Asunto principal:
Neumonía Viral
/
Infecciones por Coronavirus
/
Peptidil-Dipeptidasa A
/
Pandemias
Límite:
Humanos
Idioma:
Inglés
Revista:
Braz. arch. biol. technol
Asunto de la revista:
Biologia
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Diyarlife Hospital/TR
/
Kartal Kosuyolu Yuksek Ihtisas Research and Training Hospital/TR
/
Sultanabdulhamid Han Training and Research Hospital/TR
/
University of Health Sciences/TR
/
Yenikent Family Health Centre/TR
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