Quorum Sensing Interfering Strategies and Their Implications in the Management of Biofilm-Associated Bacterial Infections
Braz. arch. biol. technol
;
63: e20190555, 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1132270
ABSTRACT
Abstract The bacterial species employ various types of molecular communication systems recognized as quorum sensing for the synchronization of differential gene expression to regulate virulence traits and biofilm formation. A variety of quorum sensing inhibitors; molecules that interfere with quorum sensing among bacteria have been examined which can block the action of autoinducers. Moreover, the studies have scrutinized various enzymes for their quorum quenching activity resulting in the degradation of signaling molecules or blocking of gene expression. So far, the studies have found that these approaches are not only capable to reduce the pathogenicity and biofilm formation but also resulted in increased bacterial susceptibility to antibiotics and bacteriophages. The effectiveness of these strategies has been validated in different animal models and it seems that these practices will be transformed in near future to develop the medical devices including catheters, implants, and dressings for the prevention of bacterial infections. Although many of these approaches are still in the research stage, the increasing library of quorum quenching molecules and enzymes will open innovative perspectives for the development of antibacterial approaches which will extend the therapeutic arsenal against the pathogenic bacterial species.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Infecciones Bacterianas
/
Biopelículas
/
Percepción de Quorum
/
Antibacterianos
Tipo de estudio:
Factores de riesgo
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. arch. biol. technol
Asunto de la revista:
Biologia
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Pakistán
Institución/País de afiliación:
Government College University Faisalabad/PK
Similares
MEDLINE
...
LILACS
LIS