Antibacterial Activity of Sophorolipids from Candida bombicola Against Human Pathogens
Braz. arch. biol. technol
;
63: e20180568, 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1132273
ABSTRACT
Abstract Sophorolipids are glycolipids that have natural antimicrobial properties and present great potential in the pharmaceutical field. The present study aimed to produce sophorolipids from Candida bombicola using a chicken fat-based medium and evaluate the antimicrobial activity against Gram-negative (Proteus mirabilis, Escherichia coli, Salmonella enterica subsp. enterica) and Gram-positive bacteria (Enterococcus faecium, Staphylococcus aureus and Streptococcus mutans). The production of sophorolipids reached 27.86 g L-1. Based on the structural characterization, 73.55% of the sophorolipids present a mixture of acidic monoacetylated C182 and lactonic diacetylated C160, and 26.45% were present in the diacetylated C181 lactonic form. Bacteria submitted to sophorolipid exposure showed a reduction in viability at doses of 500 μg mL-1 and 2,000 μg mL-1 against Gram-positive and Gram-negative bacteria, respectively. These results suggest that sophorolipids produced in chicken fat medium may be used as antimicrobial agents to prevent or eliminate contamination by different pathogens.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Candida
/
Glucolípidos
/
Enterococcus faecium
/
Bacterias Gramnegativas
/
Antibacterianos
Idioma:
Inglés
Revista:
Braz. arch. biol. technol
Asunto de la revista:
Biologia
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
State University of Londrina/BR
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