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Clinical and laboratory parameters as predictors of long-term outcome according to the etiology of underlying chronic liver disease in patients who underwent liver transplantation for hepatocellular carcinoma treatment
Diniz, Paulo Henrique Costa; Silva, Serena Dafne do Carmo; Faria, Luciana Costa; Vidigal, Paula Vieira Teixeira; Ferrari, Teresa Cristina de Abreu.
Afiliación
  • Diniz, Paulo Henrique Costa; Hospital das Clinicas, Universidade Federal de Minas Gerais. Servico de Oncologia. Belo Horizonte. BR
  • Silva, Serena Dafne do Carmo; Hospital das Clinicas, Universidade Federal de Minas Gerais. Servico de Oncologia. Belo Horizonte. BR
  • Faria, Luciana Costa; Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais. Belo Horizonte. BR
  • Vidigal, Paula Vieira Teixeira; Departamento de Anatomia Patologica e Medicina Legal, Faculdade de Medicina, Universidade Federal de Minas Gerais. Belo Horizonte. BR
  • Ferrari, Teresa Cristina de Abreu; Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais. Belo Horizonte. BR
Clinics ; Clinics;75: e1529, 2020. tab, graf
Article en En | LILACS | ID: biblio-1133368
Biblioteca responsable: BR1.1
ABSTRACT

OBJECTIVES:

This study aimed to analyze clinical and laboratory parameters and their association with long-term outcomes in patients who underwent liver transplantation for hepatocellular carcinoma treatment, according to the etiology of the underlying chronic liver disease, in order to identify predictors of response to this therapeutic modality.

METHODS:

Demographic, clinical, and laboratory data from a cohort of 134 patients who underwent orthotopic liver transplantation for hepatocellular carcinoma treatment at a referral center in Brazil were retrospectively selected and compared according to the etiologic group of the underlying chronic liver disease. Events, defined as tumor recurrence or death from any cause, and event-free survival were also analyzed, and multivariate analysis was performed.

RESULTS:

The etiologies comprised hepatitis C and B virus infection, alcohol abuse, and cryptogenic disorder. Although liver transplantation was performed outside the Milan criteria in 33.3% of the subjects, according to pathologic examination of the explanted liver, the Model for End-Stage Liver Disease score was low (<22) in most patients (70.6%) and recurrence was identified in only 10 (7.9%) patients. Events occurred in 37 patients (28.5%), and the median event-free survival was 75 months (range, 24-116 months). No difference among etiologic groups was found in the parameters analyzed, which were not independently associated with outcome.

CONCLUSION:

Clinical and laboratory characteristics according to etiologic groups were not different, which might have led to comparable long-term outcomes among these patient groups and failure to identify predictors that could aid in better selection of subjects for liver transplantation in the management of this cancer.
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Texto completo: 1 Índice: LILACS Asunto principal: Trasplante de Hígado / Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Clinics Asunto de la revista: MEDICINA Año: 2020 Tipo del documento: Article

Texto completo: 1 Índice: LILACS Asunto principal: Trasplante de Hígado / Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Clinics Asunto de la revista: MEDICINA Año: 2020 Tipo del documento: Article