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Association between antioxidant vitamins and oxidative stress among patients with a complete hydatidiform mole
Ferraz, Leda; Ramos, Catharina Albiero Bueno; Braga, Antônio; Velarde, Luis Guillermo Coca; Elias, Kevin M; Horowitz, Neil S; Lopes, Patrícia Fátima; Berkowitz, Ross S.
  • Ferraz, Leda; Universidade Federal Fluminense. Programa de Pos-Graduacao em Ciencias Medicas. Niteroi. BR
  • Ramos, Catharina Albiero Bueno; Universidade Federal Fluminense. Programa de Pos-Graduacao em Ciencias Medicas. Niteroi. BR
  • Braga, Antônio; Universidade Federal Fluminense. Programa de Pos-Graduacao em Ciencias Medicas. Niteroi. BR
  • Velarde, Luis Guillermo Coca; Universidade Federal Fluminense. Programa de Pos-Graduacao em Ciencias Medicas. Niteroi. BR
  • Elias, Kevin M; Dana-Farber Cancer Institute. New England Trophoblastic Disease Center. Division of Gynecologic Oncology. Boston. US
  • Horowitz, Neil S; Dana-Farber Cancer Institute. New England Trophoblastic Disease Center. Division of Gynecologic Oncology. Boston. US
  • Lopes, Patrícia Fátima; Universidade Federal Fluminense. Programa de Pos-Graduacao em Ciencias Medicas. Niteroi. BR
  • Berkowitz, Ross S; Dana-Farber Cancer Institute. New England Trophoblastic Disease Center. Division of Gynecologic Oncology. Boston. US
Clinics ; 75: e1724, 2020. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1133456
ABSTRACT

OBJECTIVES:

This study aimed to evaluate the potential relationship between oxidative stress, dietary intake, and serum levels of antioxidants in patients with a complete hydatidiform mole (CHM) compared with controls.

METHODS:

This was an observational cross-sectional study conducted in Rio de Janeiro, Brazil. A total of 140 women were enrolled in this study and divided into four groups 43 patients with CHM, 33 women who had had an abortion, 32 healthy pregnant women, and 32 healthy non-pregnant women. All participants underwent blood sampling, assessment using a semiquantitative food frequency questionnaire, and anthropometric measurement. Blood samples were collected after overnight fasting (10-12 h). Vitamin levels (A, C, and E) were determined by ultra-performance liquid chromatography, and gamma-glutamyl transferase levels were assessed using an automated quantitative analysis system (Dimension®, Siemens).

RESULTS:

Although all groups showed sufficient serum vitamin A and E levels, the participants had inadequate dietary intake of these vitamins. Conversely, all groups had an insufficient serum level of vitamin C, despite adequate intake. The gamma-glutamyl transferase values did not differ significantly among the groups. However, elevated serum levels of this enzyme were observed in several patients.

CONCLUSIONS:

All groups exhibited high levels of oxidative stress, as evaluated by gamma-glutamyl transferase levels, and had inadequate intake of antioxidant vitamins. Therefore, the high exposure to oxidative stress found in our study, even in healthy pregnant and non-pregnant women, may increase the incidence of CHM in this region.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Mola Hidatiforme Tipo de estudio: Estudio observacional / Estudio de prevalencia / Factores de riesgo Límite: Femenino / Humanos / Embarazo País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Clinics Asunto de la revista: Medicina Año: 2020 Tipo del documento: Artículo País de afiliación: Brasil / Estados Unidos Institución/País de afiliación: Dana-Farber Cancer Institute/US / Universidade Federal Fluminense/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Mola Hidatiforme Tipo de estudio: Estudio observacional / Estudio de prevalencia / Factores de riesgo Límite: Femenino / Humanos / Embarazo País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Clinics Asunto de la revista: Medicina Año: 2020 Tipo del documento: Artículo País de afiliación: Brasil / Estados Unidos Institución/País de afiliación: Dana-Farber Cancer Institute/US / Universidade Federal Fluminense/BR