Plasma Renin in Women Using and not Using Combined Oral Contraceptive
Int. j. cardiovasc. sci. (Impr.)
;
33(3): 208-214, May-June 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1134363
ABSTRACT
Abstract Backgroud Recent studies show that women on combined oral contraceptives (COC) present abnormal fasting lipid profile, increased postprandial lipemia, plasma C-reactive protein (CRP) and blood pressure (BP) compared to women not on combined oral contraceptives. Plasma renin is one of the factors responsible for abnormal BP. Objectives:
To assess plasma renin levels in women using or not using COC, the correlation between renin and CRP, as well as divergences in lipid profile.Methods:
A cross-sectional study with apparently healthy women aged 20 to 30, eutrophic, irregularly active, and with fasting triglycerides < 150 mg/dL. The sample was stratified into two groups the No Combined Oral Contraceptive Group (NCOCG), comprised of women who did not use any type of hormone contraceptive, and the Combined Oral Contraceptive Group (COCG) comprised of women on low-dose COC for at least one year. After a 12-hour fast, 5 ml of blood was collected for renin dosing and PCR. Data were analyzed by the t-Test and bidirectional Mann-Whitney Test, both with significance < 0.05.Results:
We evaluated 44 women equally distributed between the groups, age 23 ± 1.2 years, BMI 21.0 ± 3.2 kg/m2. Median and interquartile deviation of renin in the NCOCG and the COCG were, respectively, 0.5 (0.1-1.0) and 3.0 (2-6) (p < 0.01). A positive correlation between PCR and renin (p < 0.01 and r = 0.68) was found.Conclusion:
The plasma renin levels of women using COC were higher, with a strong correlation with CRP.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Renina
/
Anticonceptivos Orales Combinados
/
Presión Arterial
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Int. j. cardiovasc. sci. (Impr.)
Asunto de la revista:
Cardiología
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Centro Universitário Social da Bahia/BR
/
Escola Bahiana de Medicina e Saúde Pública/BR
Similares
MEDLINE
...
LILACS
LIS