Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients
Mem. Inst. Oswaldo Cruz
; 115: e200082, 2020. tab, graf
Article
en En
| LILACS, SES-SP
| ID: biblio-1135226
Biblioteca responsable:
BR1.1
ABSTRACT
Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/AIDS inpatients with RF. A flow cytometry assay for reactive oxygen species (ROS) showed lower levels in platelets of these patients in relation to the healthy subjects. However, when stimulated with adrenaline, ROS levels increased in platelets and platelet-derived microparticles of HIV/AIDS inpatients, which may increase the risk of RF during HIV and tuberculosis (HIV-TB) coinfection.
Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Insuficiencia Respiratoria
/
Infecciones por VIH
/
VIH
/
Especies Reactivas de Oxígeno
/
Micropartículas Derivadas de Células
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
2020
Tipo del documento:
Article