Genomic and phylogenetic characterisation of an imported case of SARS-CoV-2 in Amazonas State, Brazil
Mem. Inst. Oswaldo Cruz
;
115: e200310, 2020. tab, graf
Artículo
en Inglés
| LILACS, SES-SP
| ID: biblio-1135251
ABSTRACT
A new coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] is currently causing a life-threatening pandemic. In this study, we report the complete genome sequencing and genetic characterisation of a SARS-CoV-2 detected in Manaus, Amazonas, Brazil, and the protocol we designed to generate high-quality SARS-CoV-2 full genome data. The isolate was obtained from an asymptomatic carrier returning from Madrid, Spain. Nucleotide sequence analysis showed a total of nine mutations in comparison with the original human case in Wuhan, China, and support this case as belonging to the recently proposed lineage A.2. Phylogeographic analysis further confirmed the likely European origin of this case. To our knowledge, this is the first SARS-CoV-2 genome obtained from the North Brazilian Region. We believe that the information generated in this study may contribute to the ongoing efforts toward the SARS-CoV-2 emergence.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Filogenia
/
Neumonía Viral
/
Infecciones por Coronavirus
/
Betacoronavirus
Límite:
Humanos
País/Región como asunto:
America del Sur
/
Brasil
/
Europa
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Fundação Oswaldo Cruz-Fiocruz/BR
/
Fundação de Vigilância em Saúde do Amazonas/BR
/
Universidade Federal do Espírito Santo/BR
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