Increased platelet distribution width and reduced IL-2 and IL-12 are associated with thrombocytopenia in Plasmodium vivax malaria
Mem. Inst. Oswaldo Cruz
;
115: e200080, 2020. tab, graf
Artículo
en Inglés
| LILACS, SES-SP
| ID: biblio-1135269
ABSTRACT
BACKGROUND Thrombocytopenia in malaria involves platelet destruction and consumption; however, the cellular response underlying this phenomenon has still not been elucidated. OBJECTIVE To find associations between platelet indices and unbalanced Th1/Th2/Th17 cytokines as a response to thrombocytopenia in Plasmodium vivax infected (Pv-MAL) patients. METHODS Platelet counts and quantification of Th1/Th2/Th17 cytokine levels were compared in 77 patients with uncomplicated P. vivax malaria and 37 healthy donors from the same area (endemic control group - ENCG). FINDINGS Thrombocytopenia was the main manifestation in 55 patients, but was not associated with parasitaemia. The Pv-MAL patients showed increases in the mean platelet volume (MPV), which may be consistent with larger or megaplatelets. Contrary to the findings regarding the endemic control group, MPV and platelet distribution width (PDW) did not show an inverse correlation, due the increase in the heterogeneity of platelet width. In addition, the Pv-MAL patients presented increased IL-1β and reduced IL-12p70 and IL-2 serum concentrations. Furthermore, the reduction of these cytokines was associated with PDW values. MAIN CONCLUSIONS Our data demonstrate that an increase in MPV and the association between reductions of IL-2 and IL-12 and PDW values may be an immune response to thrombocytopenia in uncomplicated P. vivax malaria.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Plasmodium vivax
/
Trombocitopenia
/
Subgrupos Linfocitarios
/
Malaria Vivax
Tipo de estudio:
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas/BR
/
Fundação Oswaldo Cruz-Fiocruz/BR
/
Fundação de Medicina Tropical Dr Heitor Vieira Dourado/BR
/
Universidade Estadual de Campinas/BR
/
Universidade do Estado do Amazonas/BR
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