In vitro-induction of metronidazole-resistant Giardia duodenalis is not associated with nucleotide alterations in the genes involved in pro-drug activation
Mem. Inst. Oswaldo Cruz
;
115: e200303, 2020. tab, graf
Artículo
en Inglés
| LILACS, SES-SP
| ID: biblio-1135270
ABSTRACT
Giardiasis is an infectious disease caused by Giardia duodenalis. The pro-drug metronidazole (MTZ) is the first-line treatment for giardiasis. Parasite's proteins as pyruvateferredoxin oxidoreductase (PFOR), ferredoxin (Fd), nitroreductase-1 (NR-1) and thioredoxin reductase (TrxR) participate in MTZ activation. Here, we showed Giardia trophozoites long-term exposed to MTZ presented higher IC50 than controls, showing the drug influenced the parasite survival. That reduction in MTZ's susceptibility does not seem to be related to mutations in the genes pfor, fd, nr-1 or trxr. It points that different mechanism as alterations in other metabolic pathways can account for Giardia resistance to MTZ therapy.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Resistencia a Medicamentos
/
Profármacos
/
Giardia lamblia
/
Metronidazol
/
Antiprotozoarios
Tipo de estudio:
Factores de riesgo
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Fundação Oswaldo Cruz-Fiocruz/BR
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