Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19
Rev. Soc. Bras. Med. Trop
;
53: e20200477, 2020. tab, graf
Artículo
en Inglés
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1136842
ABSTRACT
Abstract Recent reports indicate that besides respiratory and systemic symptoms among coronavirus disease (COVID-19) patients, the disease has a wide spectrum of neurological manifestations (encephalitis, meningitis, myelitis, acute disseminated encephalomyelitis, metabolic and acute hemorrhagic necrotizing encephalopathy, cerebrovascular diseases, Guillain-Barré syndrome, polyneuritis cranialis, dysautonomia, and myopathies). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can spread from the respiratory system to the central nervous system, using transneuronal and hematogenous mechanisms. Although not every COVID-19 patient will test positive for the virus in the cerebrospinal fluid exam, the appearance of neurological symptoms associated with SARS-CoV-2 infection reveals the importance of understanding the neurologic manifestations and capacity for neural invasion associated with the pathogen. These aspects are relevant for correct diagnosis and treatment, and for the potential development of vaccines. This review highlights the latest evidence of SARS-CoV-2 infection with a focus on neurological involvement and potential neuropathogenesis mechanisms.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neumonía Viral
/
Enfermedades del Sistema Nervioso Central
/
Infecciones por Coronavirus
/
Pandemias
/
Betacoronavirus
Tipo de estudio:
Estudio diagnóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Universidade Federal do Estado do Rio de Janeiro/BR
/
Universidade Federal do Rio de Janeiro/BR
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