Transmission and prevalence of drug-resistant tuberculosis in a Brazilian setting under a directly observed therapy short-course strategy
Rev. Soc. Bras. Med. Trop
; Rev. Soc. Bras. Med. Trop;53: e20190404, 2020. tab, graf
Article
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| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1136910
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
We aimed to estimate the prevalence and transmission of drug-resistant tuberculosis in a high-burden Brazilian setting under directly observed therapy short-course strategy.METHODS:
Isolates of culture-confirmed pulmonary tuberculosis patients from Guarulhos, Brazil, diagnosed in October 2007-2011 were subjected to drug susceptibility and IS6110-restriction fragment length polymorphism testing.RESULTS:
The overall resistance prevalence was 11.5% and the multi-drug resistance rate was 4.2%. Twenty-six (43.3%) of 60 drug-resistant isolates were clustered. Epidemiological relationships were identified in 11 (42.3%) patients; 30.8% of the cases were transmitted in households.CONCLUSIONS:
Drug-resistant tuberculosis was relatively low and transmitted in households and the community.Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Polimorfismo de Longitud del Fragmento de Restricción
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Brasil
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Prevalencia
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Estudios Transversales
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Tuberculosis Resistente a Múltiples Medicamentos
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Terapia por Observación Directa
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Mycobacterium tuberculosis
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
MEDICINA TROPICAL
Año:
2020
Tipo del documento:
Article