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The role of vaccinium myrtillus in the prevention of renal injury in an experimental model of ruptured abdominal aortic aneurysm
Ergene, Saban; Hemsinli, Dogus; Karakisi, Sedat Ozan; Mercantepe, Tolga; Tumkaya, Levent; Yilmaz, Adnan.
  • Ergene, Saban; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Cardiovascular Surgery. Rize. TR
  • Hemsinli, Dogus; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Cardiovascular Surgery. Rize. TR
  • Karakisi, Sedat Ozan; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Cardiovascular Surgery. Rize. TR
  • Mercantepe, Tolga; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Histology and Embryology. Rize. TR
  • Tumkaya, Levent; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Histology and Embryology. Rize. TR
  • Yilmaz, Adnan; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Medical Biochemistry. Rize. TR
Rev. bras. cir. cardiovasc ; 35(4): 490-497, July-Aug. 2020. tab, graf
Artículo en Inglés | LILACS, SES-SP | ID: biblio-1137292
ABSTRACT
Abstract

Objective:

To examine the biochemical and histopathological renal effects of ischemia/reperfusion (I/R) injury using a ruptured abdominal aortic aneurysm (RAAA) model in rats and to investigate the potential protective effects of whortleberry (Vaccinium myrtillus).

Methods:

Thirty-two male Sprague-Dawley rats were randomly assigned into four groups - control, sham (I/R+glycerol), I/R, and I/R+whortleberry. Midline laparotomy alone was performed in the control group. Atraumatic abdominal clamps were attached under anesthesia to the abdominal aorta beneath the level of the renal artery in the groups subjected to I/R. Sixty-minute reperfusion was established one hour after ischemia. The sham group received five intraperitoneal doses of glycerol five days before I/R. The I/R+whortleberry group received a single intraperitoneal 50 mg/kg dose diluted with saline solution five days before I/R. All animals were finally euthanized by cervical dislocation following 60-min reperfusion.

Results:

Increases were observed in malondialdehyde (MDA) levels and tubular necrosis scores (TNS) in thin kidney tissues and in numbers of apoptotic renal tubule cells, together with a decrease in glutathione (GSH) levels, in sham and I/R groups. In contrast, we observed a decrease in MDA levels, TNS, and numbers of apoptotic renal tubule cells, and an increase in GSH levels with whortleberry treatment compared to the I/R group.

Conclusion:

Our findings suggest that whortleberry may be effective against acute kidney injury by reducing oxidative stress and apoptosis.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Daño por Reperfusión / Aneurisma de la Aorta Abdominal / Vaccinium myrtillus Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Rev. bras. cir. cardiovasc Año: 2020 Tipo del documento: Artículo Institución/País de afiliación: Recep Tayyip Erdogan University/TR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Daño por Reperfusión / Aneurisma de la Aorta Abdominal / Vaccinium myrtillus Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Rev. bras. cir. cardiovasc Año: 2020 Tipo del documento: Artículo Institución/País de afiliación: Recep Tayyip Erdogan University/TR