Role of urotensin-ii in saphenous vein graft disease
Rev. bras. cir. cardiovasc
;
35(5): 675-682, Sept.-Oct. 2020. tab, graf
Artículo
en Inglés
| LILACS, SES-SP
| ID: biblio-1137356
ABSTRACT
Abstract Objective:
To elucidate the effect of diabetes mellitus (DM) on the atherosclerotic process in saphenous vein grafts by determining urotensin-II (U-II) levels in harvested saphenous veins of patients who underwent coronary artery bypass grafting (CABG).Methods:
Coronary artery disease (CAD) patients who underwent CABG were divided into two groups Group I (eight non-diabetic patients; CAD group) and Group II (13 patients; DM+CAD group). All patients underwent coronary angiography prior to surgery and Gensini score was used to determine the severity of coronary atherosclerosis. Saphenous vein samples were stained with hematoxylin-eosin and U-II, then damage score, H-Score, and vein layer thicknesses were calculated and statistically evaluated.Results:
In light microscopic evaluation, significant difference was observed between the groups in terms of endothelial cells damage, internal elastic lamina degradation, and tunica media vascular smooth muscle cells (VSMCs) damage (P<0.001). U-II immunoreactivity was increased in tunica adventitia in the DM+CAD group (P=0.002). The increase in foam cells was directly proportional to the thickening of the subendothelial layer, and this increased U-II immunoreactivity. Gensini score was higher in the DM+CAD group than in the CAD group (P=0.002).Conclusion:
Our results show that saphenous vein grafts are already atherosclerotic before they are grafted in CAD patients. This disease is more severe in diabetic CAD patients and these changes can be detected using U-II immunoreactivity.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Urotensinas
/
Enfermedad de la Arteria Coronaria
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Rev. bras. cir. cardiovasc
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Mersin City Training and Research Hospital/TR
/
Mersin University/TR
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