Nutritional status and appetite-regulating hormones in early treatment of acute lymphoblastic leukemia among children and adolescents: a cohort study
São Paulo med. j
;
138(2): 118-125, Mar.-Apr. 2020. tab, graf
Artículo
en Inglés
| LILACS, SES-SP
| ID: biblio-1139668
ABSTRACT
ABSTRACT BACKGROUND:
Children with acute lymphoblastic leukemia are at risk of malnutrition, but few studies have described the changes in nutritional status during the different phases of chemotherapy.OBJECTIVE:
To evaluate changes in nutritional status, food intake and appetite-regulating hormones among children and adolescents with acute lymphoblastic leukemia in the first phase of chemotherapy. DESIGN ANDSETTING:
Cohort study developed in the pediatric oncology departments of two hospitals in the city of Natal, Rio Grande do Norte, Brazil.METHODS:
Fourteen children/adolescents (mean age of 7 years; 50% female) with acute lymphoblastic leukemia were monitored over the 28 days of an induction chemotherapy cycle. Anthropometric measurements, 24-hours food weight records and appetite-regulating hormone levels (ghrelin, leptin, insulin and cortisol) were obtained at three different times (before, in the middle and at the end of the induction phase).RESULTS:
Most of the patients (85.7%) had normal weight at the beginning of the treatment, and this did not change significantly during the 28 days. Energy and nutrient intakes improved from the start of the treatment to the midpoint, according to the ghrelin levels (from 511.1 ± 8.3 to 519.3 ± 6.6 pg/ml; P = 0.027). Other appetite-regulating hormones did not present changes.CONCLUSION:
Food consumption improves during the first phase of treatment, without alterations in anthropometric nutritional status.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Apetito
/
Leucemia-Linfoma Linfoblástico de Células Precursoras B
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Factores de riesgo
Límite:
Adolescente
/
Niño
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
São Paulo med. j
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Fundação Universitária de Cardiologia/BR
/
Universidade Federal de Ciências da Saúde de Porto Alegre/BR
/
Universidade Federal do Rio Grande do Norte/BR
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