Association of serum levels of secreted frizzled-related protein 5 and Wnt member 5a with glomerular filtration rate in patients with type 2 diabetes mellitus and chronic renal disease: a cross-sectional study
São Paulo med. j
;
138(2): 133-139, Mar.-Apr. 2020. tab, graf
Artículo
en Inglés
| LILACS, SES-SP
| ID: biblio-1139677
ABSTRACT
ABSTRACT BACKGROUND:
Diabetic nephropathy is a common complication of chronic kidney disease (CKD). Inflammation in the kidneys is crucial for promoting development and progression of this complication. Wnt member 5a (Wnt5a) and secreted frizzled-related protein 5 (Sfrp5) are proinflammatory proteins associated with insulin resistance and chronic low-grade adipose tissue inflammation.OBJECTIVE:
To determine the correlation between serum Sfrp5 and Wnt5a concentrations and glomerular filtration rate in patients with type 2 diabetes mellitus and CKD. DESIGN ANDSETTING:
Cross-sectional, comparative and observational study in the Department of Endocrinology, Civil Hospital, Culiacán, Sinaloa, Mexico.METHODS:
Eighty individuals with chronic kidney disease were recruited. Their serum Sfrp5 and Wnt5a concentrations were quantified using the enzyme-linked immunosorbent assay (ELISA) test. The statistical analysis consisted of the Mann-Whitney U test for independent samples and Spearman correlation, with statistical significance of P < 0.05.RESULTS:
Serum Sfrp5 concentration continually increased through the stages of CKD progression, whereas serum Wnt5a concentration presented its highest levels in stage 3 CKD. Negative correlations between estimated glomerular filtration rate (eGFR) and serum concentrations of Sfrp5 (r = -0434, P = 0.001) and Wnt5a (r = -0481, P = 0.001) were found.CONCLUSIONS:
There were negative correlations between serum Sfrp5 and Wnt5a concentrations and eGFR at each stage of CKD, with higher levels in female patients. This phenomenon suggests that Sfrp5 and Wnt5a might be involved in development and evolution towards end-stage renal disease.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Péptidos y Proteínas de Señalización Intracelular
/
Diabetes Mellitus Tipo 2
/
Insuficiencia Renal Crónica
/
Fallo Renal Crónico
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Femenino
/
Humanos
País/Región como asunto:
México
Idioma:
Inglés
Revista:
São Paulo med. j
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Centro de Investigación y Docencia en Ciencias de la Salud/MX
/
Instituto Mexicano del Seguro Social/MX
/
Universidad Autónoma de Sinaloa/MX
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