Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
Rev. Soc. Bras. Med. Trop
;
54: e01452020, 2021. tab, graf
Artículo
en Inglés
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1143891
ABSTRACT
Abstract INTRODUCTION:
We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.METHODS:
This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.RESULTS:
A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.CONCLUSIONS:
This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Esquistosomiasis
/
Lectina de Unión a Manosa
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Animales
/
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Año:
2021
Tipo del documento:
Artículo
Institución/País de afiliación:
Universidade Federal de Pernambuco/BR
/
Universidade de Pernambuco/BR
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