COVID-19 and patients with immune-mediated inflammatory diseases undergoing pharmacological treatments: a rapid living systematic review
São Paulo med. j
;
138(6): 515-520, Nov.-Dec. 2020. tab, graf
Artículo
en Inglés
| LILACS, SES-SP
| ID: biblio-1145126
ABSTRACT
ABSTRACT BACKGROUND:
Patients with immune-mediated inflammatory diseases (IMID) are at increased risk of infection.OBJECTIVE:
To assess whether patients undergoing pharmacological treatment for IMID present higher risk of worse outcomes when diagnosed with COVID-19. DESIGN ANDSETTING:
Rapid systematic review conducted in the medical school of the Federal University of São Paulo (SP), Brazil.METHODS:
We searched CENTRAL, MEDLINE, EMBASE, LILACS, SCOPUS, Web of Science, L·OVE, ClinicalTrials.gov and WHO-ICTRP for studies evaluating patients diagnosed with COVID-19 who were undergoing pharmacological treatment for IMID. Two authors selected studies, extracted data and assessed risk of bias and certainty of evidence, following the Cochrane recommendations.RESULTS:
We identified 1,498 references, from which one cohort study was included. This compared patients with and without rheumatic diseases (RD) who all had been diagnosed with COVID-19. Those with RD seemed to have higher chances of hospitalization and mortality, but no statistical difference was detected between the groups hospitalization odds ratio (OR) 1.17; 95% confidence interval (CI) 0.6 to 2.29; mortality rate OR 1.53; 95% CI 0.33 to 7.11 (very low certainty of evidence). Patients with RD were three times more likely to require admission to intensive care units (ICUs), with invasive mechanical ventilation (IMV), than those without RD OR 3.72; 95% CI 1.35 to 10.26 (for both outcomes; very low certainty of evidence).CONCLUSION:
Patients undergoing pharmacological treatment for IMID seem to present higher chances of requiring admission to ICUs, with IMV. Additional high-quality studies are needed to analyze the effects of different treatments for IMID.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Artritis Reumatoide
/
COVID-19
Tipo de estudio:
Estudio de etiología
/
Guía de Práctica Clínica
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
São Paulo med. j
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Beneficência Portuguesa de São Paulo/BR
/
Universidade Federal de São Paulo/BR
/
Universidade Ibirapuera/BR
/
Universidade Santo Amaro/BR
Similares
MEDLINE
...
LILACS
LIS