Human african trypanosomiasis: current standing and challenges
Rev. patol. trop
;
49(3)2020.
Artículo
en Inglés
| LILACS
| ID: biblio-1151970
ABSTRACT
Human African trypanosomiasis (HAT) caused by the protozoan Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, and transmitted by the tsetse fly (genus Glossina), affects 36 Sub-Saharan African countries with considerable public health impact. Despite approximately 15,000 infected individuals and 70 million at risk, in recent years the World Health Organization has mentioned removal of HAT from the list of Neglected Tropical Diseases by 2020, due to the decrease in cases over the last two decades. When untreated, the disease presents high lethality rates and the available treatments are complicated to administer, highly toxic, and do not guarantee cure, especially in the advanced stages of the disease. Further, there is no prospect for vaccine development in the near future. The present review compiles information on the history of the clinical aspects of HAT, as well as its epidemiology, diagnosis, therapy, and prophylaxis, as well as updating information on the current panorama and perspectives regarding the disease.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Trypanosoma brucei gambiense
/
Tripanosomiasis Africana
/
Moscas Tse-Tse
/
Trypanosoma brucei rhodesiense
/
Enfermedades Desatendidas
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. patol. trop
Asunto de la revista:
Medicina Tropical
/
Patología
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Centro Universitário Serra dos Orgãos/BR
/
Universidade Federal de Minas Gerais/BR
/
Universidade Federal de Viçosa/BR
/
Universidade Federal do Vale do Jequitinhonha e Mucuri/BR
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