Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019
Rev. Soc. Bras. Med. Trop
;
54: e0728-2020, 2021. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1155535
ABSTRACT
Abstract INTRODUCTION:
Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.METHODS:
MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.RESULTS:
Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V).CONCLUSIONS:
The proportion of mono-SM-resistant TB among new patients was higher.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Preparaciones Farmacéuticas
/
Tuberculosis Resistente a Múltiples Medicamentos
/
Mycobacterium tuberculosis
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Hangzhou Center for Disease Control and Prevention/CN
/
Zhejiang University/CN
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