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Early hematological parameters as predictors for outcomes in children with dengue in northern India: A retrospective analysis
Nandwani, Sumi; Bhakhri, Bhanu Kiran; Singh, Nupur; Rai, Ruchi; Singh, Dharmender Kumar.
  • Nandwani, Sumi; Superspecialty Pediatric Hospital & Postgraduate Teaching Institute. Department of Microbiology. Noida. IN
  • Bhakhri, Bhanu Kiran; Superspecialty Pediatric Hospital & Postgraduate Teaching Institute. Department of Pediatrics. Noida. IN
  • Singh, Nupur; Superspecialty Pediatric Hospital & Postgraduate Teaching Institute. Department of Pediatrics. Noida. IN
  • Rai, Ruchi; Superspecialty Pediatric Hospital & Postgraduate Teaching Institute. Department of Neonatology. Noida. IN
  • Singh, Dharmender Kumar; Superspecialty Pediatric Hospital & Postgraduate Teaching Institute. Department of Pediatrics. Noida. IN
Rev. Soc. Bras. Med. Trop ; 54: e05192020, 2021. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1155590
ABSTRACT
Abstract

INTRODUCTION:

Dengue presents with a variable clinical course, ranging from mild illness to potentially fatal hemorrhage and shock. We aimed to evaluate the capabilities of various hematological parameters observed early in the course of illness for predicting the clinical outcomes of illness.

METHODS:

We retrospectively analyzed the records of children admitted in the pediatric inpatient services of the institute with dengue between 2017 and 2019. We determined the relationships between the hematological parameters observed during the first evaluation and the various clinical outcomes.

RESULTS:

We evaluated data from 613 patients (age range, 26 days to 17 years). Of these, 29.85% exhibited fever with warning signs, and 8.97% had severe dengue. Lower values of hemoglobin, platelet count, mean corpuscular volume, mean corpuscular hemoglobin concentration, and mean platelet volume, and higher values of total leukocyte count (TLC), hematocrit, and red cell distribution width variably correlated with numerous clinical outcomes-duration of hospital stay, development of complications, requirement of blood component transfusion, inotropic support, and mortality. Among the parameters, TLC ≥20,000/mL and initial platelet count ≤20,000/mL significantly associated with mortality, with odds ratios (95% confidence interval) of 11.81 (4.21-33.80) and 5.53 (1.90-16.09), respectively.

CONCLUSIONS:

Hematological parameters observed early during dengue infection may predict its clinical outcomes in infected children. Initial high TLC and low platelet count are potential predictors of fatal outcomes in the course of disease.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Dengue Grave / Dengue Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adulto / Niño / Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Rev. Soc. Bras. Med. Trop Asunto de la revista: Medicina Tropical Año: 2021 Tipo del documento: Artículo País de afiliación: India Institución/País de afiliación: Superspecialty Pediatric Hospital & Postgraduate Teaching Institute/IN

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Dengue Grave / Dengue Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adulto / Niño / Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Rev. Soc. Bras. Med. Trop Asunto de la revista: Medicina Tropical Año: 2021 Tipo del documento: Artículo País de afiliación: India Institución/País de afiliación: Superspecialty Pediatric Hospital & Postgraduate Teaching Institute/IN