Apoptosis e infección por el virus de la inmunodeficiencia humana (HIV) / [Apoptosis and human immunodeficiency virus infection (HIV]
Medicina (B.Aires)
;
60 Suppl 2: 17-20, 2000.
Artículo
en Español
| LILACS, BINACIS
| ID: biblio-1165065
ABSTRACT
Generalized activation of the immune system after HIV infection leads to an exacerbation of all apoptotic mechanisms. CD4+, CD8+ T lymphocytes and B lymphocytes are sensitized to apoptotic stimuli. Macrophages are important in the removal of apoptotic cells, they prevent apoptotic cell accumulation during in vitro culture and they may lead to enhanced CD4+ T lymphocyte cell death through indirect mechanisms. A simple procedure for prolonged culture of peripheral blood mononuclear cells from HIV+ patients is discussed, in relation to its convenience to evaluate apoptosis, cell to cell interaction and HIV replication in the absence of exogenously added stimuli or co-culture of allogeneic cells. In this system, HIV replication takes place primarily in cells of macrophage lineage that may be activated into differentiation through removal of apoptotic debris during the culture.
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Índice:
LILACS (Américas)
Asunto principal:
Linfocitos T CD4-Positivos
/
Infecciones por VIH
/
VIH
/
Apoptosis
Límite:
Humanos
Idioma:
Español
Revista:
Medicina (B.Aires)
Asunto de la revista:
Medicina
Año:
2000
Tipo del documento:
Artículo
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