Single lesion leprosy pacients multicentric cohort treated with single dose drug therapy: findings on three-year follow-up and public health perspective in Brazil
In. Universidade Federal do Rio de Janeiro.Instituto de Estudos em Saúde Coletiva. Investigações em sistema de saúde e controle da hanseníase. Rio de Janeiro, s.n, abr.-jun., 2008. p.363-376.
No convencional
en Inglés
| LILACS, SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1247260
ABSTRACT
Single skin lesion, paucibacillary (SSL-PB) leprosy is considered and early disease manifesation. This study the clinical outcome of a cohort of 259 newly diagnosed SSL-PB treated with one dose of rifampicin, ofloxacin, minocycline (ROM) and followed-up for three-years. Patients were recruited from the North, Central West and Southeast regions in Brazil (1997-2001). The result expected with ROM therapy was disappearance or the reduction of lesion size. Manifestation that required additional intervention were considered as poor clinical outcome:
type-1 reaction (T1R) with or without neuritis alone, increase in lesion size and shift from paucibacillary to multibacillary. The incidence of poor clinical outcome was calculated by person-month and with the Kaplan-Meier methods. 61.8% of the participants were females, mean age 32.2, and 67,2% had borderline tuberculoid (BT) or tuberculoid forms. T1R was the predominant event; shift from paucibacillary to multibacillaru was rare. 92.0% of the volunteers shown no events during the first year, the same occurring to 80.6% of them after 3 years of clinical monitoring. The probability of remaining event-free was highest among those 40 years old or younger. Poor outcome predominated among BT patients. Extended monitoring of SSL-PB leprosy cases under minimal therapy provided valuable case management information for reference centers.
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Índice:
LILACS (Américas)
Asunto principal:
Dosis Única
/
Salud Pública
/
Lepra
Tipo de estudio:
Estudio diagnóstico
/
Factores de riesgo
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Año:
2008
Tipo del documento:
No convencional
Institución/País de afiliación:
Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta/BR
/
Governo do Estado do Amazonas/BR
/
Hospital Dr. Marcello Cândia/BR
/
Instituto Oswaldo Cruz/BR
/
Secretária de Saúde de Rondônia/BR
/
Universidade Federal de Goiás/BR
/
Universidade Federal do Rio de Janeiro/BR
/
Universidade do Estado do Rio de Janeiro/BR
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