External Apical Root Resorption and IL-1A, IL-1RN Gene Polymorphisms: A Systematic Review and Meta-Analysis of Prospective Studies
Pesqui. bras. odontopediatria clín. integr
;
21: e0217, 2021. tab, graf
Artículo
en Inglés
| LILACS, BBO
| ID: biblio-1250442
ABSTRACT
ABSTRACT Objective:
To reconnoiter the IL-1A (-889) and IL-1RN (+2018) gene polymorphisms and their association with EARR. Material andMethods:
The Science Direct, PubMed and Scopus databases were comprehensively searched by two independent reviewers. In addition, the bibliographies of all relevant publications and textbooks were searched manually. A meta-analysis was performed using data available up to May 9, 2020.Results:
A total of 13 and 9 publications were selected for the systematic review and meta-analysis, respectively for both IL-1A and IL-1RN genes. Odds ratio (OR) was used to evaluate the association of the gene polymorphism and the risk of EARR. The risk of EARR was estimated using the overall OR from the published studies. No association was found for IL-1A gene for the risk of EARR. However, the dominant and co-dominant models of IL-1RN gene polymorphism were associated with the risk of EARR.Conclusion:
More studies are warranted to determine the relationship between IL-1A and IL-1RN gene polymorphisms and EARR for a clearer understanding of their interactions.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Ortodoncia
/
Polimorfismo Genético
/
Resorción Radicular
/
Heterogeneidad Genética
/
Proteína Antagonista del Receptor de Interleucina 1
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
/
Revisiones Sistemáticas Evaluadas
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Pesqui. bras. odontopediatria clín. integr
Asunto de la revista:
Odontología
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Malasia
/
Arabia Saudita
Institución/País de afiliación:
Jouf University/SA
/
Universiti Sains Malaysia/MY
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