Immunology of cervical cancer
Rev. invest. clín
;
72(4): 188-197, Jul.-Aug. 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1251856
ABSTRACT
ABSTRACT Optimal function of the immune system allows the recognition and elimination of infected and tumor cells. However, these cells can develop mechanisms to evade the cellular immune response. In human papillomavirus (HPV) infection, dysregulation of major histocompatibility complex Class I molecules and other components of the innate immune system promote the survival of infected cells by allowing the infection to persist which, in turn, favors the development of cancer. Further, tumor cells possess inherent mechanisms designed to block the recognition and activation of cytotoxic lymphocytes particularly, HPV proteins such as E1 and E2 and oncoproteins E5, E6, and E7 that inhibit immune mechanisms and/or stimulate the expression of immunosuppressive cytokines. These mechanisms include a decrease in receptor activation and costimulating molecules on the surface of immune cells, as well as the constitutive expression of molecules that inhibit their function, which allow HPV persistence and tumor progression. Immunotherapy-based therapeutic options are positioned as excellent candidates for the treatment of cervical cancer.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Antígenos de Histocompatibilidad Clase I
/
Neoplasias del Cuello Uterino
/
Proteínas Oncogénicas Virales
/
Infecciones por Papillomavirus
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Rev. invest. clín
Asunto de la revista:
Medicina
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
Dinamarca
/
México
Institución/País de afiliación:
Instituto Nacional de Cancerología/MX
/
Instituto Nacional de Salud Pública/MX
/
Universidad Nacional Autónoma de México/MX
/
Universidad de Guadalajara/MX
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