Lack of efficacy of the standard potency Edmonston-Zagreb live, attenuated measles vaccine in African infants
Bull. W.H.O. (Online)
;
69(2): 221227-1991. ilus
Artículo
en Inglés
| AIM
| ID: biblio-1259777
ABSTRACT
The efficacy of standard potency Edmonston-Zagreb (E-Z) measles vaccine was tested in a randomized trial of Black infants in a rural area of South Africa where a measles epidemic was occurring. The following immunization schedules were used 48 infants aged 4-8.5 months who received 3.9 log 50 infectious units of E-Z vaccine (group A); 48 infants aged 4-8.5 months who received 3.28 log 50 infectious units of Schwarz vaccine (group B); and 28 infants aged greater than 9 months who received 3.28 log 50 infectious units of Schwarz vaccine and served as controls (group C). For infants aged less than 23 weeks who were given either the E-Z or Schwarz vaccine, the number of seropositives was low (28%), irrespective of the pre-vaccination level of measles antibody. There was a higher number of seropositives (68%) among those in the age range greater than 23 weeks to less than 36 weeks who received the E-Z vaccine rather than the Schwarz vaccine (36%). When administered to children aged greater than 36 weeks, the Schwarz vaccine produced a satisfactory, though suboptimal response rate (61%). There was no correlation between seropositivity and pre-vaccination measles antibody status. Use of the standard dose of E-Z vaccine may have been one of the factors for this poor response, and this supports the WHO recommendation that titres higher than the standard potency vaccine are needed if 6-month-old infants are to be successfully immunized against measles
Texto completo:
Disponible
Índice:
AIM (África)
Asunto principal:
Sudáfrica
/
Inmunoglobulina G
/
Vacuna Antisarampión
/
Estudios Seroepidemiológicos
/
Alotipos de Inmunoglobulinas
/
Sarampión
Tipo de estudio:
Ensayo Clínico Controlado
País/Región como asunto:
Africa
Idioma:
Inglés
Revista:
Bull. W.H.O. (Online)
Año:
1991
Tipo del documento:
Artículo
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