Intermittent preventive treatment for malaria in infants: a decision-support tool for sub-saharan Africa
Bull. W.H.O. (Online)
; 88(11): 807814-2010. ilus
Article
en En
| AIM
| ID: biblio-1259853
Biblioteca responsable:
CG1.1
ABSTRACT
Objective To develop a decision-support tool to help policy-makers in sub-Saharan Africa assess whether intermittent preventive treatment in infants (IPTi) would be effective for local malaria control. Methods An algorithm for predicting the effect of IPTi was developed using two approaches. First; study data on the age patterns of clinical cases of Plasmodium falciparum malaria; hospital admissions for infection with malaria parasites and malaria-associated death for different levels of malaria transmission intensity and seasonality were used to estimate the percentage of cases of these outcomes that would occur in children aged 10 years targeted by IPTi. Second; a previously developed stochastic mathematical model of IPTi was used to predict the number of cases likely to be averted by implementing IPTi under different epidemiological conditions. The decision-support tool uses the data from these two approaches that are most relevant to the context specified by the user. Findings Findings from the two approaches indicated that the percentage of cases targeted by IPTi increases with the severity of the malaria outcome and with transmission intensity. The decision-support tool; available on the Internet; provides estimates of the percentage of malaria-associated deaths; hospitalizations and clinical cases that will be targeted by IPTi in a specified context and of the number of these outcomes that could be averted. Conclusion The effectiveness of IPTi varies with malaria transmission intensity and seasonality. Deciding where to implement IPTi must take into account the local epidemiology of malaria. The Internet-based decision-support tool described here predicts the likely effectiveness of IPTi under a wide range of epidemiological conditions
Texto completo:
1
Índice:
AIM
Asunto principal:
Plasmodium malariae
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Técnicas de Apoyo para la Decisión
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África del Sur del Sahara
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Lactante
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Malaria
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Antimaláricos
Tipo de estudio:
Prognostic_studies
País/Región como asunto:
Africa
Idioma:
En
Revista:
Bull. W.H.O. (Online)
Año:
2010
Tipo del documento:
Article