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The Protective Effect of Topical Rifamycin Treatment against Sternal Wound Infection in Diabetic Patients Undergoing on-Pump Coronary Artery Bypass Graft Surgery : Cardiovascular Topic
Akpek, Mahmut; Aygun, Fatih; Kaya, Mehmet G; Keser, Ahmet; Kuzgun, Ahmet; Ulucan, Seref.
  • Akpek, Mahmut; s.af
  • Aygun, Fatih; s.af
  • Kaya, Mehmet G; s.af
  • Keser, Ahmet; s.af
  • Kuzgun, Ahmet; s.af
  • Ulucan, Seref; s.af
Cardiovasc. j. Afr. (Online) ; 25(3): 96-99, 2014.
Artículo en Inglés | AIM | ID: biblio-1260435
ABSTRACT

Objectives:

The aim of this study was to investigate the protective effect of topical rifamycin SV treatment against sternal wound infection (SWI) in diabetic patients undergoing on-pump coronary artery bypass graft (CABG) surgery.

Methods:

One hundred and fifty-nine diabetic patients who were scheduled to undergo isolated on-pump CABG surgery were included. Eight were excluded for various reasons. Of the 151 patients; 51 were on insulin therapy and 100 were on oral anti-diabetics. The risk of mediastinitis was assessed using the American College of Cardiology/American Heart Association 2004 guideline update for CABG surgery. According to the risk scores; patients were divided into two comparable groups the rifamycin group (n = 78) received topical rifamycin treatment after on-pump CABG surgery; and the control group (n = 73) received no topical treatment.

Results:

Deep sternal wound infection (mediastinitis) was not observed in either group (0/78 vs 0/73; p = 1.0). No superficial sternal wound infection was observed in the rifamycin group; however; it did occur in one patient in the control group (0/78 vs 1/73; p = 0.303). Wound culture was performed and coagulase-negative staphylococci were observed. The infection regressed on initiation of antibiotic therapy against isolated bacteria and the patient was discharged after a full recovery.

Conclusion:

Although the difference in rate of superficial sternal wound infection (SSWI) in the rifamycin and control groups was not statistically significant; locally applied rifamycin SV during closure of the sternum in the CABG operation may have had a protective affect against SWI
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Índice: AIM (África) Asunto principal: Infección de Heridas / Diabetes Mellitus Tipo de estudio: Guía de Práctica Clínica Idioma: Inglés Revista: Cardiovasc. j. Afr. (Online) Año: 2014 Tipo del documento: Artículo

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Índice: AIM (África) Asunto principal: Infección de Heridas / Diabetes Mellitus Tipo de estudio: Guía de Práctica Clínica Idioma: Inglés Revista: Cardiovasc. j. Afr. (Online) Año: 2014 Tipo del documento: Artículo