Acute changes in haematocrit leading to polycythaemia in late-onset hypogonadism patients that receive testosterone replacement therapy: a South African study
JEMDSA (Online)
;
24(2): 37-40, 2019.
Artículo
en Inglés
| AIM
| ID: biblio-1263764
ABSTRACT
Background:
According to the literature, parenteral testosterone replacement therapy (TRT)-induced polycythaemia is associated with cardiovascular events. No or minimal data exist for the prevalence of TRT-induced polycythaemia in late- onset hypogonadism (LOH) patients from South Africa. Polycythaemia is the side effect most frequently associated with parental TRT formulations.Design:
This was a quantitative, observational, descriptive, retrospective study.Setting:
The study setting was a private practice male clinic in Emalahleni. Subject An all-inclusive sampling method was used. Outcomemeasures:
The main outcome measure for polycythaemia was haematocrit (Hct). An Hct percentage of > 50% at month 3 (post-treatment initiation) constituted a positive diagnosis for polycythaemia. For the rise in total testosterone (TT) and Hct, the variance was used as documented between pre- and post-treatment initiation.Results:
The prevalence of polycythaemia was 34%. A statistically significant increase in both TT and Hct was observed. The Cohen'sdeffect size was 0.68 and 0.73, respectively, for TT and Hct.Conclusion:
Depot-testosterone undecanoate parenteral formulation induces polycythaemia in LOH patients, where the rise in TT demonstrates the effectiveness of therapy
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Índice:
AIM (África)
Asunto principal:
Policitemia
/
Sudáfrica
/
Degeneraciones Espinocerebelosas
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
País/Región como asunto:
Africa
Idioma:
Inglés
Revista:
JEMDSA (Online)
Año:
2019
Tipo del documento:
Artículo
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